منابع مشابه
GLP-1: the oracle for gastric bypass?
Despite enormous efforts to find effective pharmacological targets, bariatric surgery is still the most effective treatment for morbid obesity. Beyond weight loss, this procedure often results in remarkable improvements in type 2 diabetes (T2D). However, several clinical trials have shown that between 22 and 28% of patients with T2D did not experience improvements in their diabetes after surger...
متن کاملGLP-1--a candidate humoral mediator for glucose control after Roux-en-Y gastric bypass.
The worldwide increase in obesity is associated with a higher prevalence of type 2 diabetes (T2D), and severe obesity occurs with the greatest risk (1). Bariatric surgery is currently the most effective treatment not only for weight loss but also for prevention or treatment of T2D in such patients (2). It leads to remission or improvement of T2D in the majority of morbidly obese (3,4). Roux-en-...
متن کاملGLP-1 as a mediator in the remission of type 2 diabetes after gastric bypass and sleeve gastrectomy surgery.
Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) have been shown to cause remarkable improvement in type 2 diabetes, often with complete remission within days after surgery and before any significant weight loss (1). The mechanisms explaining the benefit on glycemic control independent of weight loss are still not entirely clear, but enhanced postprandial insulin secretion induced by...
متن کاملElevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues.
OBJECTIVE It has been suggested that weight reduction and improvements in satiety after Roux-en-Y gastric bypass (RYGB) are partly mediated via postoperative neuroendocrine changes. Glucagon-like peptide-1 (GLP-1) is a gut hormone secreted after food ingestion and is associated with appetite and weight reduction, mediated via effects on the central nervous system (CNS). Secretion of GLP-1 is gr...
متن کاملMini-Gastric Bypass/One-Anastomosis Gastric Bypass—Standardizing the Name
To the Editor: After performing many of the alternatives in bariatric surgery during more than two decades, we read with interest the initial ideas Dr. Rutledge proposed in regard to the Bmini-gastric bypass^ (MGB) and embraced the possibility of performing a very effective operation with fewer risks [1]. Concerned about its major criticism, wemodified the original version of theMGB in order to...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes
سال: 2014
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db13-1708